Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

Article Abstract:

Combinatorial biosynthesis was applied to reconstitute 'unnatural natural gene clusters' for the biosynthesis of four D-deoxysugars to provide Streptomyces the capability to synthesize the four D-deoxysugars. It was found that constructed gene clusters were used to increase the capabilities of microorganisms to synthesize new deoxysugars to produce new glycosylated bioactive compounds.

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Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

Article Abstract:

The biosynthetic gene cluster for the aromatic polyketide steffimycin of the anthracycline family was cloned and characterized from 'Streptomyces steffisburgensis' NRRL 3193. Sequence analysis of a 42.8-kbp DNA region revealed the 36 open reading frames (ORFs) (one of them incomplete), 24 of which spanning 26.5 kb, are probably involved in steffimycin biosynthesis.

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Deoxysugar transfer during chromomycin A(sub 3) biosynthesis in Streptomyees griseus subsp. griseus: New derivatives with antitumor activity

Article Abstract:

A study was conducted on the biosynthesis of chromomycin A(sub 3), produced by Streptomyces griseus and other streptomycete species, using the antitumor properties of an antitumor drug. It was observed that a biosynthetic pathway was proposed for the glycosylation events in chromomycin A(sub 3) biosynthesis.

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