Molecular genetics of prostate cancer

Article Abstract:

Molecular genetics of prostate cancer are discussed in this review article. Recent progress toward understanding parameters of normal vs abnormal prostatic development and of finding a molecular pathway for prostate cancer progress is covered focusing on key regulatory molecules implicated by analysis of patterns of allelic loss in human prostate cancer and/or by reverse genetic approaches in mice. Topics include correlation with aging, environmental factors, familial inheritance, and heterogeneity and multifocality.

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naked cuticle targets dishevelled to antagonize Wnt signal transduction

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The ways in which Nkd limits Wg signaling by using a combination of genetic and biochemical approaches are discussed. Study results indicate that Nkd likely can antagonize Wg signaling cell-autonomously through a direct interaction with Dsh. In Drosophila embryos the protein Naked cuticle limits effects of the Wnt signal Wingless in early segmentation.

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Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development

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It has been shown, using gene targeting, that two closely related proteins, MBD2 and MBD3, are not functionally redundant in mice. MBD3, based on genetic and biochemical data, seems to be a key component of the Mi-2/NuRD corepressor complex. MBD2 may be one of a number of factors that can recruit the complex to DNA. Maternal behavior is defective and a component of MeCP1 is missing in Mdb2(-/-) mice.

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