Clonal origin and evolution of a transmissible cancer

Article Abstract:

The genetic markers including major histocompatibility (MHC) genes, microsatellites and mitochondrial deoxyribonucleic acid (mtDNA) in naturally occurring tumors and matched blood samples are analyzed to test the hypothesis that the transmissible agent causing canine transmissible venereal tumor (CTVT) is the tumor itself. The findings, based on several independent genetic markers in tumor-bearing dogs living on five continents, show that CTVT arose from a common ancestral neoplastic cell.

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The singular history of a canine transmissible tumor

Article Abstract:

A study confirms that the infectious agent of canine transmissible venereal tumor is the cancer cell itself and that the tumor is clonal in origin. These results have implications for understanding the relationship between genome instability and transmissible cancer and for conservation biology, canine genomics, and companion animal medicine.

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Infectogenomics: Insights from the host genome into infectious diseases

Article Abstract:

The functional genomics of the host is of crucial importance in analyzing host-pathogen interactions. Infectogenomics can be harnessed to identify infectious states, to understand host response, to predict disease outcomes, to monitor responses to antimicrobial therapies, and to indicate promising new types of treatment.

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