Cleavage of the plasma membrane Na+/Ca(super 2)+ exchanger in excitotoxicity

Article Abstract:

The major plasma membrane Ca(super 2)+ extruding system, the Na+/Ca(super 2)+ exchanger (NCX) that is cleared during brain ischemia and in neurons undergoing excitotoxicity is described. Proteolytic inactivation of NCX-driven neuronal Ca(super 2)+ extrusion is responsible for the delayed excitotoxic Ca(super 2)+ deregulation and neuronal death.

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The latest waves in calcium signaling

Article Abstract:

The contributions of Ca(super 2+) and Ca(super 2+) binding proteins to health and disease were addressed in a meeting held in April 2005 in Bnaff, Canada. Insights got from the mechanical studies offered the potential for new therapeutic approaches to combat a variety of diseases resulting from alterations in Ca(super 2+) homeostasis.

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Neuroprotection in Ischemia: Blocking calcium-permeable acid-sensing ion channels

Article Abstract:

Ca(super 2+) toxicity remains the central focus of ischemic brain injury, and acidosis is a common feature of ischemia. The study shows that acidosis activates Ca(super 2+)-permeable acid-sensing ion channels (ASICs).

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