Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders

Article Abstract:

Studies have revealed that the machinery for flagellar assembly/disassembly is regulated by homologs of mitotic proteins, that cilia play essential roles in sensory transduction. Mutations in cilia/basal body proteins are responsible for cilia-related human disorders from polycystic kidney disease to a syndrome associated with obesity and diabetes.

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Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis

Article Abstract:

The repertoire of specialized proteins needed for the formation and function of cilia is defined. A comparative genomics is used to analyze the genomes of organisms with prototypical cilia, modified cilia, or no cilia and identified approximately 200 genes that are absent in the genomes of nonciliated eukaryotes.

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Life without centrioles: Cilia in the spotlight

Article Abstract:

Centrioles are vital cellular components that form the main architectural core of both centrosomes and basal bodies, the nucleating structures of cilia. The lack of sensory cilia has shown that acentriolar flies can develop normally but die early in adulthood.

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