Influence of infected cell growth state on bacteriophage reactivation levels

Article Abstract:

Pseudomonas aeruginosa can reactivate UV-damaged bacteriophages by dark repair more efficiently when infected during the stationary phase of growth or during starvation. The extent of reactivation also depended on the type of bacteriophage.

author: Kadavy, Dana R., Nickerson, Kenneth W., Shaffer, Julie J., Lott, Susan E., Wolf, Thomas A., Bolton, Cathy E., Gallimore, William H., Martin, Eugene L., Kokjohn, Tyler A.
DNA repair

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Prevalence of broad-host-range lytic bacteriophages of Sphaerotilus natans, Escherichia coli, and Pseudomonas aeruginosa

Article Abstract:

Two bacteriophage collections' abilities to form plaques on multiple bacterial host species were examined. Nine of the 10 phages analyzed were found to be broad-host-range bacteriophages. Findings demonstrated that a multiple-host environment protocol may be more effective for the isolation of bacteriophages by avoiding the selection bias inherent in single-host methods. Transduction was generated by at least two of the broad-host-range bacteriophages.

author: Nickerson, Kenneth W., Kokjohn, Tyler A., Jensen, Ellen C., Schrader, Holly S., Rieland, Brenda, Thompson, Thomas L., Lee, Kit W.
Host-bacteria relationships

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Characterization of Pseudomonas aeruginosa bacteriophage UNL-1, a bacterial virus with a novel UV-A-inducible DNA damage reactivation phenotype

Article Abstract:

The lytic virus of Pseudomonas aeruginosa, UNL-1, was observed to express a novel inducible DNA damage reactivation activity in UV-A-irradiated P. aeruginosa host cells. The expression of bacteriophage reactivation was quantified in hosts exposed to either UV-C or UV-A radiation. Around 13-fold induction was observed in UV-A-irradiated host cells. When host cells were exposed to sunlight, reactivation of damaged UNL-1 virus increased eightfold. Findings suggest that a combination of host and virus DNA repair processes contributes to replication of aquatic bacterial viruses.

author: Shaffer, Julie J., Martin, Eugene L., Kokjohn, Tyler A., Schrader, John O., Lee, Kit W., Jacobsen, Lisa M.
Genetic aspects, DNA damage, Pseudomonas aeruginosa

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subjects list: Research, Bacteriophages
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