Article Abstract:
Forty five Caenorhabditis elegans mutants were identified using lectins from wheatgerm and soybeans. The recessive mutations spans six genes, namely srf-2, srf-3, srf-4, srf-5, srf-8 and srf-9. srf-2, -3 and -5 mutants are essentially normal except for their different lectin-binding reaction. On the other hand, the other three mutants possess various structural abnormalities in addition to aberant lectin reaction. Among these defects are aberant egg-laying, movement incoordination and abnormal morphogenesis of the copulatory bursa.
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Article Abstract:
The role of two genes, daf-2 and age-1, in enhancing the lifespan of the nematode Caenorhabditis elegans was determined by examining their lifespan pathways. Mutations suppressed the lifespan extension of age-1 and daf-2 mutants. They also prompted the formation of dauer larva in the latter. Combination of the activities of these mutants with those of daf-16 and daf-18 extended their longevity despite the mutations. These results suggest that age-1 and daf-1 use the same lifespan pathway.
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Article Abstract:
Genetic behavior and function of the neurotransmitter acetylcholine were examined by applying genetic and molecular analyses on synaptic transmission in Caenorhabditis elegans. The study focused particularly on inhibitor-resistant mutants of the transmitter-hydrolizing enzyme acetylcholinesterase. Mutant acetylcholine levels indicated presynaptic functions for some genes.
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