Changes in developmental state: demolish the old to construct the new

Article Abstract:

The authors review publications on epigenetically determined patterns of gene expression. The topics include the relationship between transcriptional regulators of mating type of ubiquitin-mediated protein degradation pathway, and the importance of proteolysis for erroneous subsequent transcriptional state prevention and for gene expression program ending.

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Developmentally induced changes in transcriptional program alter spatial organization across chromosomes

Article Abstract:

The changes in nuclear organization accompanying stimulus by the mating pheromone alpha factor of the Saccharomyces cerevisiae is examined. The results reveal RNA- and DNA-dependent determinants of nuclear organization and a detailed picture of how an entire chromosome alters its spatial conformation in response to a developmental cue.

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Regulation of transcription factor latency by receptor-activated proteolysis

Article Abstract:

The mechanism responsible for the amino acid-induced processing of the transcription factor stp1 is pursued in response to extracellular amino acids by the plasma membrane SPS (Ssy1-Ptr3-Ssy5)-sensor. The results demonstrate that regulating the enzymatic activity of an intracellular endoprotease could control gene expression.

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