Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis

Article Abstract:

Genetic and molecular evidence that the histone acetyltransferase (HAT) Chameau and the histone deacetylase DRpd3 act as antagonistic cofactors of DJun and DFos to modulate Jun N-terminal kinase (JNK)-dependent transcription during thorax metamorphosis and JNK-induced apoptosis in Drosophila. It is demonstrated in cultured cells that DFos phosphorylation mediated by JNK signaling plays a central role in coordinating the dynamics of Chameau and DRpd3 recruitment and function at AP-1-responsive promoters.

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Chromatin remodeling and activation of chromosomal DNA replication by an acidic transcriptional activation domain from BRCA1

Article Abstract:

Several genetic transcription factors have been discovered to influence DNA replication, yet the precise mechanism has not been found. Increasing chromatin accessibility might be a crucial mechanism of transcription factors during multiple nuclear processes. This has been suggested by observing that the acidic transcriptional activation domain of the breast cancer BRCA1 can alter local chromatin structure while stimulating DNA replication.

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Repression by Suppressor of Hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo

Article Abstract:

Research has been conducted on the Notch signal transduction. The binding of DNA and activation of Notch target gene transcription has been discussed.

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