Cell type-specific effects of Rb deletion in the murine retina

Article Abstract:

The role of Rb in normal retinal development and in retinoblastoma using conditional Rb mutations in the mouse is studied. The results revealed that Rb mutation combined with p170 and with p130 mutation caused retinal dysplasia or retinoblastomas with amacrine cell characteristics, whereas most major cell types were affected by Rb mutation, amacrine cells were able to develop and survive.

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TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.

Article Abstract:

A study on contribution of TopBP1(DNA topoisomerase II beta binding protein 1) in regulating E2F1(transcriptional activity) - mediated apoptosis is conducted. The results reveal that E2F1 is regulated by a novel Retinoblastoma protein(pRb)-independent mechanism in which TopBP1 recruits Brg1/Brm, thus, preventing apoptosis during DNA replication.

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pRB family proteins are required for H3K27 trimethylation and polycomb repression complexes binding to and silencing [p16.sup.INK4a] tumor suppressor gene

Article Abstract:

A study demonstrates that polycomb genes EZH2 and BM11 repress p16 expression in human and mouse primary cells but not in cells deficient for pRB protein function. The findings suggest a model wherein pRB proteins recruit PRC2 to trimethylate p16, priming the BMI1-containing PRC1L ubiquitin ligase complex to silence p16.d

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