Cell fate decisions within the mouse organizer are governed by graded Nodal signals

Article Abstract:

Research has been conducted on cell fate decisions. Results demonstrate that these decisions are governed by graded Noda1/Smad2 signals, and that Smad2-dependent signals regulate the formation of PCP precursor populations and the definitive endoderm.

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Article Abstract:

Research has been conducted on tuberous sclerosis complex-2. The authors demonstrate that this complex has GTPase-activating protein activity toward Rheb in vitro, and that tuberous sclerosis complex-2 regulates Rheb-GTP levels in vivo.

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Protein ISGylation modulates the JAK-STAT signaling pathway

Article Abstract:

Research has been conducted on protease removing ISG15 from ISGylated proteins. The authors demonstrate that the mice lacking this protease are hypersensitive to type I interferon.

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