Cell cycle control by an essential bacterial two-component signal transduction protein

Article Abstract:

Cell cycle processes in in the bacterium Caulobacter crescentus are regulated by a protein designated as CtrA. The protein has a structure similar to response regulator proteins which are involved in signal transduction, and its non-expression in the cell is lethal for the cell. It functions in initiating cell division, the formation of the bacterium's flagellum and in transcription. Specifically, it binds to DNA which contains a promoter sequence that starts these multiple events in the cell cycle.

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MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter

Article Abstract:

The identification of a protein, MipZ that travels with the chormosomal origin region and couples midcell localization of the FtsZ ring with the initiation of chromosome replication and segregation is presented. This has provided a mechanism to integrate both the temporal and spatial control of cell division in a single regulatory system.

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A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator

Article Abstract:

The dynamic localization of ClpX and ClpP subunits of the ClpXP protease to the incipient stalked cell pole coincident with CtrA polar localization is discussed. CtrA proteolysis is mediated at the appropriate time in the cell cycle by the dynamic polar positioning of the ClpXP protease with the cytoplasmic RcdA protein.

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