Article Abstract:
A study was conducted on the role of the RAD9 gene in the arrest of 12 cell division cycle (cdc) mutants. cdc rad9 cells in four mutants were found to be incapable of arrest in the restrictive temperature. These cells continued to divide and eventually died. The cdc RAD cells, on the other hand, were able to arrest and maintained viability. Analysis of the cell cycle and genetic phenotypes of these mutants revealed that the RAD9 checkpoint function is both phase- and signal-specific. The RAD9 checkpoint was also found to require the RAD17 gene for inducing phase specific arrest. It was concluded that the RAD9 checkpoint arrests cell division during the late S/G(sub 2) phase and can be activated only by DNA lesions.
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Article Abstract:
An analysis of developmental chromosome changes that regularly occur in cell differentiation is presented. These changes include facultative heterochromatization, polyploidization by endoreduplication, under-replication and gene amplification as well as chromatin diminution and chromosome elimination. Signaling pathways and molecular mechanisms involved in the alterations in chromosomes are analyzed by using cell and molecular genetic methods.
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Article Abstract:
It is shown that Mokady and Buss' simple and strong prediction of the one-locus model to determine the formal genetics of invertebrate allorecognition in Hydractinia symbiolongicarpus is not empirically validated. This analysis therefore challenges the assertion of the researchers that a single locus influences allorecognition specificity in the invertebrate. Implications are discussed.
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