Causes, effects, and constraints in the genetics of human longevity

Article Abstract:

The heritability of longevity appears to be low, as it aggregates in families rather than segregating. Genes implicated in longevity probably affect responses to life-threatening factors, rather than directly regulating maximum life span as a distinct trait. Compensatory adaptation is an important factor in aging, involving a long-lasting adaptation in response to a defect in some organic subsystem. Such adaptation leads to a decrease in viability and possibly to irreversible and life-threatening damage associated with aging.

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Arrays of hope

Article Abstract:

The US Food and Drug Administration has launched the MicroArray Quality Control (MAQC) project to probe the microarray technology. Scientists have welcomed the MAQC consortium's Phase I data, but the FDA will have to approve expression-based microarrays so that they can be used for clinical diagnostics.

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Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance

Article Abstract:

The splice mutation in the iron-sulfur cluster scaffold protein ISCU is found to cause myopathy with exercise intolerance in patients. The other human diseases that are caused by the defects in iron-sulfur cluster biogenesis are also investigated.

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