Article Abstract:
The non-isotopic in situ hybridisation (NISH) involves visualizing fluorescent DNA and RNA probes hybridised to single cells, tissues or chromosomes. Innovations using NISH and a yeast artificial chromosome probe were used to detect the hybridisation complex present in only one X chromosome in female carriers of X-linked disorders. These were shown in female relatives of patients with Hunter syndrome and Duchenne muscular dystrophy.
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Article Abstract:
Cyclin B3 and Cyclin B are necessary for female fertility but neither is needed for mitosis in Drosophila. Cyclin B3 is found in proliferating cells during mitosis but cannot be detected in Drosophila embryos' tissues during endoreduplication. Cyclin B3 becomes degraded quickly during mitosis. Cyclin B3 is a nuclear protein, unlike Cyclins A and B, with which it cooperates in regulating mitosis.
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Article Abstract:
Strategies for rare-event detection include a technique for automated detection of rare fetal nucleated red blood cells (NRBCs) in maternal blood, an approach for which has been evaluated. Results indicate the automated microscopy and image analysis approach is more sensitive than the alternatives, cuts the workload, and can be used to find rare HbF-containing NRBCs in blood of the mother.
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