Cargo regulates clathrin-coated pit dynamics

Article Abstract:

A study was conducted to show that regulated endocytosis of G protein-coupled receptors (GPCRs) occurs preferentially through a subset of clathrin-coated pits (CCPs). Segregation of cargo into CCP subsets, combined with cargo-dependent control of CCP dynamics, proposes a simple kinetic mechanism to generate functional specialization early in the endocytic pathway and reduce competition between diverse endocytic cargo.

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Advocating asymmetry and the POP-1 paradox: Noncanonical Wnt signaling in C. elegans

Article Abstract:

The identification of a novel beta-catenin that functions in noncanonical C. elegans Wnt signaling pathways to specify the different fates of daughter cells produced by asymmetric cell division are described. The findings state that in contrast to canonical signaling, noncanonical Wnt pathways are more variable in composition but are united by their indifference to the canonical role of beta-catenin.

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RIC-8 is required for GPR-1/2-dependent G alpha function during asymmetric division of C. elegans embroys

Article Abstract:

The evolutionary conserved protein RIC-8 is needed for proper asymmetric division of one-cell stage C. A mechanism has been developed in which RIC-8 favors generation of G alpha free from G beta gamma.

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