Article Abstract:
Clostridium butyricum cells grown on glycerol show a higher carbon flow than those grown on glucose, as the NADH formed during metabolism is reoxidized by both the butyric and propanediol (PD) pathways. During growth on glycerol, glycerol dehydrogenase, 1,3-PD dehydrogenase and diol dehydratase regulate the flow of carbon to the pathways that form either acetate and butyrate, or 1,3-PD. During growth on glucose, the level of acetyl-CoA and NADH in the cells increases.
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Article Abstract:
Molar growth yields have been observed to be reduced when Clostridium cellulolyticum was cultured in media with cellobiose. Continuous cultures were studied to discover the reason for such poor growth yields. Findings indicated that a decreased NADH reoxidation may be the cause of the restricted C. cellulolyticum growth. Lactate and ethanol production were not enough to balance out the NADH produced in the glyceraldehyde-3-phosphate dehydrogenase step of glycolysis.
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Article Abstract:
Examination of the sporulation behavior of Clostridium cellulolyticum cells as a function of different cellobiose growth conditions reveals that starving cells exhibit a sporulation of 30% during the exponential phase of growth, while cell sporulation is absent at the beginning of the growth. Proteolytic activities and sporulation are inhibited by high levels of cellobiose. Cells from the late stationary growth phase exhibit the highest adhesion to filter paper.
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