Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans

Article Abstract:

The phagocytosis of degenerating cells during development in Caenorhabditis elegans by other cells is mediated by a number of genes. One of these genes is ced-6, the gene product of which, CED-6, is responsible for phagocytosis of cells in early and late stages of degeneration. The amino terminus of CED-6 contains a domain that binds phosphotyrosine. CED-6 appears to be an adaptor molecule that mediates signal transduction between engulfing and degenerating cells.

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CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

Article Abstract:

The signaling pathway genes ced-12 and elmo-1 participate in the phagocytosis and cell migration in Caenorhabditis elegans and mammals, respectively. Data indicate that CED12/ELMO-1 binds directly to CED-5/Dock180 and stimulates a Rac-GEF, which leads to Rac1 activation.

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Apoptosis: corralling the corpses

Article Abstract:

The author reviews publications on the apoptosis and how quickly it happens. The point of interest include the importance of apoptosis in physiology and pathology, the origins and the nature of the "eat me" signals and the signaling pathways responding to these signals.

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