Article Abstract:
DNA fingerprinting of the isolates of the fungus Candida obtained from HIV-positive individuals in Dublin and Australia shows that the these isolates constitute a new species for which the name C. dubliniensis has been proposed. These isolates are germ-tube-positive and produce a large number of chlamydospores arranged in pairs or triplets. The organization of the genome in these isolates is different from that of C. albicans and C. stellatoidea but the clusters formed by these species are similar. A description of C. dubliniensis is given.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Four isolates of Candida dubliniensis and two standard strains of C. albicans were compared to determine the phylogenetic relationship between the two strains and identify the virulence factors in C. dubliniensis. Results reveal a close phylogenetic relationship between the two Candida species. The elevated proteinase production in C. dubliniensis and its reduced ability to form hyphae may be the reason why this pathogen is nearly always associated with oral candidiasis.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A technique for the rapid identification of Candida dubliniensis colonies in as little as four hours has been devised. The methodology makes use of phylogenetic trees derived from ACT1 exon and intron sequences from a variety of yeast species. The technique was developed by taking advantage of the substantial difference between C. dublinienis and C. albicans ACT1 intron by designing PCR primers that are specific only to C. dubliniensis.
User Contributions:
Comment about this article or add new information about this topic: