Cadherin superfamily genes: functions, genomic organization, and neurologic diversity

Article Abstract:

Cadherin superfamily genes and their functions, genomic organization, and neurologic diversity are discussed in this review article that related to the functions of the central nervous system and the immune system. Molecular studies of the cadherin superfamily give insights into molecular mechanisms involved in building and regulating neural networks of the brain. The immune system comes from diversification and interaction of the immunoglobulin superfamily.

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Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion

Article Abstract:

The Drosophila sticks-and-stones (sns) locus has been identified based on its mutant phenotype, absence of body wall muscles and presence of unfused myoblasts. The genetic location of the mutation that brings on the apparent defect in myoblast fusion has been found by recombination and deficiency mapping. Drosophila SNS has been found to be a member of the immunoglobulin superfamily required for myoblast fusion.

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The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions

Article Abstract:

The identification of the receptor protein tyrosine phosphates DEP-1 as a negative regulator of the Caenorhabdits elegans EGF receptor is presented. It results in full activation of the EGFR/RAS/MAPK pathway in the primary vulval cells and at the same time keeps the EGFR/RAS/MAPK pathway inactive in the adjacent secondary cells.

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