CYLD in ubiquitin signaling and tumor pathogenesis

Article Abstract:

CYLD is a tumor suppressor gene, the absence of which causes an inherited disease characterized by benign skin tumors. A study is presented to show that CYLD deubiquitinates the coactivator Bcl-3, thereby preventing its translocation into the nucleus, where it normally interacts with NF-(kappa)B and activates transcription of proliferation genes in response to growth signals.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

Article Abstract:

A single nucleotide polymorphism (SNP309) is found in the MDM2 promoter, and it is shown that it increases the affinity of the transcriptional activator Sp1, resulting in higher levels of MDM2 RNA and protein, and the subsequent attenuation of the p53 pathway. SNP309 is shown to associate with accelerated tumor formation in both hereditary and sporadic cancers in humans.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes

Article Abstract:

Gene transcription gets regulated by the retinoblastoma tumor suppressor protein (pRb). Results indicate an extensive evolutionary conservation of specific pRb repressor complexes.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: