CLASPs are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts
Article Abstract:
Two CLIP-associated proteins (CLASPs) have been isolated. CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the ends of growing microtubules and may function as anti-catastrophe factors. CLASPs are homologous to the Drosophila Orbit/Mast microtubule-associated protein and appear to be involved in the local regulation of microtubule dynamics, responding to positional cues.
author: Vermeulen, Wim, Grosveld, Frank, Akhamanova, Anna, Hoogenraad, Casper C., Stepanova, Tatiana, Dortland, Bjorn, Verkerk, Ton, Burgering, Boudewijn M., De Zeeuwk, Chris I., Galjart, Niels, Drabek, Ksenija
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Netherlands, Statistical Data Included, Cytochemistry, Fibroblasts, Cytoplasm
Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics
Article Abstract:
Research has been conducted on microtubule-associated protein CLASP1. The authors demonstrate that this protein localizes near the plus end of the growing spindle microtubules and is a kinetochore region component, and suggest that CLASP1 is important for attached microtubules to display normal dynamic behavior.
author: Sunkel, Claudio E., Swedlow, Jason R., Earnshaw, William C., Maiato, Helder, Fairley, Elizabeth A. L., Reider, Conly L.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
United States, Portugal, Scotland, Analysis, Cell research, Cytological research, Kinetochores
The microtubule plus-end tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis
Article Abstract:
The function of mouse cytoplasmic linker protein of 170 kDa (CLIP-170) is examined. It is found that Clip-170 is able to act both as a (+)TIP and as a structural protein and is also important for normal spermatogenesis.
author: Medema, Rene H., Grosveld, Frank, Hoogenraad, Casper C., Stepanova, Tatiana, Galjart, Niels, Drabek, Ksenija, Akhmanova, Anna, Mausset-Bonnefont, Anne-Laure, Cappellen, Wiggert van, Keihzer, Nanda, Wees, Jacqueline van der, Mommaas, Mieke, Onderwater, Jos, Meulen, Hans van der, Tanenbaum, Marvin E., Hoogerbrugge, Jos, Vreeburg, Jan, Uringa, Evert-Jan, Grootegoed, J.Anton
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
Science & research, Mice, House mouse, Cytoplasmic filaments, Spermatogenesis in animals, Animal spermatogenesis
subjects list: Research, Physiological aspects, Genetic aspects, Proteins, Microtubules
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