C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

Article Abstract:

Two Caenorhabditis elegans 14-3-3 proteins were identified as SIR-2.1 binding partners and it is demonstrated that 14-3-3 genes are required for the life-span extension conferred by extra copies of sir-2.1. Findings suggest the existence of a stress-dependent pathway in which SIR-2.1 and 14-3-3 may act in parallel to the insulin-like pathway to regulate DAF-16 and extend life span.

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The KEOPS complex: A rosetta stone for telomere regulation

Article Abstract:

A study is conducted to identify a new complex, called KEOPS, which promotes both telomere uncapping and elongation. The defect telomere length that is observed in KEOPS mutants is due to a defect in resection, which leads to reduced binging of Cdc13 and Rpa1, and ultimately reduced recruitment of Est1 and Est2.

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Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein

Article Abstract:

The possible role of the murine regulator of telomere length (Rtel) gene in telomere length regulation is examined by disrupting its expression in vitro and in vivo. Regulator of telomere length (Rtel) is an essential gene regulating telomere length and prevents genetic instability.

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