Boning up on ephrin signaling

Article Abstract:

The bidirectional signaling between osteoclasts, which degrade bone, and osteoblasts, which form bone, through the transmembrane ligand ephrinB2 expressed by osteoclasts and its receptor EphB4 expressed by osteoblasts is demonstrated. Results show that such bidirectional signaling limits osteoclast activity while stimulating osteoblast differentiation.

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The molecular clock mediates leptin-regulated bone formation

Article Abstract:

A study demonstrates that clock genes in osteoblasts mediate the leptin-dependant sympathetic inhibition of bone formation. The regulation of bone-formation by leptin through two antagonistic pathways is reminiscent of the dual mechanism that leptin uses to regulate bone resorption.

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The Ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans

Article Abstract:

Results demonstrate that ephrin VAB2/EFN-1 receptor, a component of the neurons, regulates epidermal morphogenesis in nematodes and serves as a ligand for VAB-1 receptor. VAB2 is expressed adjacent to VAB-1 in neurons and may partly function in a kinase-independent VAB-1 pathway.

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