Birth of a prion: Spontaneous generation revisited

Article Abstract:

Prions are the causative agents of transmissible spongiform encephalopathies (TSEs) such as Creutzfeldt-Jakob disease (CJD) in man, bovine spongiform encephalopathy (BSE) in cattle or scrapie in sheep. Study is conducted to show that the agent prion can be replicated in a cell-free system, that it can be generated de novo, and that the strain specific properties of prions can be encoded by conformational variations of the underlying protein.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription

Article Abstract:

A study is conducted to show that the DksA protein is a crucial component of ppGpp-dependent regulation. Biochemical analysis demonstrates that DksA affects transcript elongation, albeit differently from GreA, augments ppGpp effects on initiation and binds directly to RNAP, positioning the Asp residues near the active site.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

REG(gamma): A shortcut to destruction

Article Abstract:

Destruction of intact cellular proteins are largely orchestrated by ATP-dependent ubiquitination and subsequent degradation by the 26S proteasome. The proteasomal activator REG(gamma) directs degradation of the steroid receptor coactivator SRC-3 by the 20S proteasome in an ATP- and ubiquitin-independent manner.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: