Article Abstract:
A copy of the E. coli lactose operon (lacO) cassette was inserted near the replication origin of Bacillus subtilis chromosome to determine the mechanisms of Bacillus subtilis chromosome segregation. The chromosomes of Bacillus subtilis are oriented with their origins near opposite poles during the initial phase of sporulation. The origin-distal region of the forespore chromosome was then translocated to the small sporangial compartment after polar septation. Finally, the replication origin separated near either end of the sporangium after the engulfment of the forespore by the mother cell.
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Article Abstract:
Research has been conducted on the signaling pathway preventing sporulation initiation in Bacillus subtilis when the replication initiation is impaired. The isolation of the mutant which allow the sporulation of the replication initiation mutant has been carried out and the results indicate that these mutations affect a small open reading frame.
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Article Abstract:
Research has been conducted on the signaling properties of ubiquitin which depend on the polyubiquitin chain topology. The results of the crystal structure analysis of the Mms2/Ubc13 heterodimer demonstrate the active site of the Ubc13 at the intersection of the channels which are the binding sites for the substrate ubiquitins.
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