Article Abstract:
Research was conducted to examine the environmental fate of the major fungal metabolite 3,5-dichloro-p-anisyl alcohol under anaerobic conditions and its role in the formation of bis(3,5-dichloro-4-hydroxyphenyl)methane. This was performed by the incubation of the compound with methanogenic sludge and investigating its biotransformation reactions. Results suggest that 3,5-dichloro-4-p-anisyl alcohol is initially biotransformed in anaerobic environments through the demethylation reaction to 3,5-dichloro-4-hydroxybenzyl alcohol.
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Article Abstract:
The biodegradation of 2,4-diamino-6-nitrotoluene (2,4-DANT) by a Pseudomonas fluorescens species forms the metabolite 4-N-acetylamino-2-amino-6-nitrotoluene under anoxic and aerobic conditions. P. fluorescens initially reduces 2,4,6-trinitrotoluene to aminodinitrotoluenes and then to diaminonitrotoluenes under nitrate-limited conditions. The 2,4-DANT converts to the metabolite but 2,6-diamino-4-nitrotoluene is not degraded. The biodegradation is faster under anoxic conditions as compared to aerobic conditions.
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Article Abstract:
Chromatographic techniques helps isolate a cytotoxic metabolite, talarotoxin, from Talaromyces bacillosporus IFO 8397, cultured on rice. Spectroscopic study of the structure of the toxin reveals that a conjugated triene connects a pyrrolizidinedione to a trans-Delta 1-octalin. Intraperitoneal administration of the toxin leads to breathing problem in mice.
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