Beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

Article Abstract:

Research has been conducted on the beta-catenin, an important molecule in Wnt/wingless signaling which controls steps in embryogenesis. The role of beta-catenin in skin development has been investigated via the conditional mutation of the epidermis and hair follicle gene and the results indicate that beta-catenin mutation has blocked placode formation which generates hair follicles.

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Morphogenesis and renewal of hair follicles from adult multipotent stem cells

Article Abstract:

Research has been conducted on the multipotent stem cells contained in the outer root sheath of vibrissal follicles of adult mice and responding to the morphogenetic signals to generate hair follicles. Results demonstrate that these cells migrate to the root of the follicle in producing whisker growth and that the clonogenic keratinocytes are related to the multipotent stem cells.

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Signaling downstream to Eph receptors and ephrin ligands

Article Abstract:

The authors review publications on the Eph receptors and ephrin ligands in investigating molecular mechanisms of the cellular interactions which regulate axon guidance, cell migration and morphogenesis. The topics of interest include the mechanisms used by these receptors and ligands to control discrete steps in the development of the nervous system.

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