Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

Article Abstract:

The wild-type Bcl-2 antiapoptotic proteins, but not Beclin 1 binding defective mutants of Bcl-2, inhibit Beclin 1-dependent autophagy in yeast and mammalian cells and that cardiac Bcl-2 transgenic expression inhibits autophagy in mouse heart muscle. Beclin 1 mutants that cannot bind to Bcl-2 induce more autophagy than wild-type Beclin 1 and unlike wild-type Beclin 1 promote cell death.

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Autophagy regulates programmed cell death during the plant innate immune response

Article Abstract:

Plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene ATG6/VPS30/beclin 1, functions to restrict hypersensitive response (HR) programmed cell death (PCD) to infection sites. The evolutionarily conserved autophagy pathway plays an essential role in plant innate immunity and negatively regulates PCD.

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Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense

Article Abstract:

New evidence shows that autophagy is used for survival when intracellular nutrients are limited by growth factor deprivation. It is also showed that the autophagy machinery is also used to degrade foreign microbial invaders (Xenophagy).

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