Article Abstract:
Studies on 30-60 antibacterial proteins produced by gram-positive pathogenic bacteria revealed bacteriocins translated as inactive prepeptides consisting of an N-terminal leader sequence and a C-terminal propeptide sequence. The leader peptide is removed after posttranslation modification, while the propeptide components undergo dehydration and ring formation to produce lanthionine and beta-methyl lanthionine or cystine. Bacteriocin from gram-positive bacteria can exhibit different antimicrobial spectrum after site-specific mutagenesis.
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Article Abstract:
The multilocus sequence typing (MSLT) method through which it is possible to differentiate the isolates of Streptococcus uberis, which is the cause of intramammary infection of bovine mastitits, and to describe its population structure is developed. The shortfalls of the other molecular typing techniques have overcome with this system, which allows further investigation of the population biology of this organism and insights into its epidemiology of the disease.
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Article Abstract:
A report that Streptococcus uberis strain 42 produces a lantibiotic, nisin U that is identical to nisin A from ds presented. This is first such report of characterization of a bacteriocin by Streptococcus uberis as well as of a member of the nisin family of peptides in a species other than Lactococcus lactis.
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