Bacterial sex pheromone-induced plasmid transfer

Article Abstract:

The impact of plasmids and transposons in multiple antibiotic resistance is reviewed, with emphasis on the role of sex pheromones in the transfer of different conjugative plasmids. These movements are especially relevant for the recovery from diseases such as infective endocarditis. Thus, their regulation and two important systems, the pAD1 and the pCF10, are discussed. Other elements of relevance include peptides and plasmid-free strains.

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Degradation signal masking by heterodimerization of MAT-alpha-2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway

Article Abstract:

A study was conducted to test whether a1 is degraded in haploid cells. HindIII fragments supporting either the MAT-alpha or MATa loci were subcloned into low and high-copy shuttle plasmids. Results indicated that degradation determinants in a1 and alpha-2 are masked in the heterodimer. Findings also showed that the correlation between alpha-2 and a1 depend on N-terminal coiled-coil interactions.

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There's the rub: a novel ubiquitin-like modification linked to cell cycle regulation

Article Abstract:

Recent research has indicated that Eukaryotes have ubiquitin-like proteins. Although they are distinctive from ubiquitin they are linked to other proteins. They have regulatory functions that are not linked to proteolysis. The new findings in the filed and the implications are dicussed.

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