BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of trancriptional activators of the mammalian clock system

Article Abstract:

Research has been conducted on mammalian CLOCK and BMAL1 proteins. The authors have investigated the abundance, circular localization and posttranslational modifications of endogenous and ectopically expressed CLOCK and BMAL1 proteins, and they report that the regulation of transcriptional activity and availability of CLOCK/BMAL1 complex is responsible for the additional level of circadian system control.

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TSC2 mediates cellular energy response to control cell growth and survival

Article Abstract:

Research shows that the tumor suppressor gene TSC2 regulates the common mTOR pathway, involved in protein synthesis, cell growth, and viability in response to cellular energy status. Results show that under energy-deprived conditions, TSC2 is phosphorylated, enhancing its activity, to facilitate translation regulation and cell size control during tuberous sclerosis complex (TSC).

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Article Abstract:

Research has been conducted on tuberous sclerosis complex-2. The authors demonstrate that this complex has GTPase-activating protein activity toward Rheb in vitro, and that tuberous sclerosis complex-2 regulates Rheb-GTP levels in vivo.

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