BDNF variant linked to anxiety-related behaviors

Article Abstract:

The impact of methionine (Met) substitution of precursor called proBDNF, which is proteolytically cleaved to generate mature brain-derived neurotrophic factor (BDNF), on anxiety-related behaviors is examined. The results have indicated that the single nucleotide polymorphism might be a modifying genetic factor in the expression of a number of normal and abnormal brain conditions, suggesting a new direction in the therapeutic strategies to treat anxiety symptoms in humans with the Met allele.

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Current approaches to pathological pain

Article Abstract:

The issues relating to pathological pains discussed detail at Novartis Foundation Symposium held in Tsukuba, Japan are detailed. The symposium focused on recent advances in molecular to systematic changes in neural systems, which are involved in pathological pain.

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What is new about ADP-ribosylation?

Article Abstract:

The 53rd Fujihara International Seminar entitled 'New Challenges in Research on ADP-ribose Metabolism' was held in Tomokomai, Japan on July 26-29, 2004. The new advances in the field of poly(ADP-ribose) polymerases were discussed at the seminar.

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