Genetic ablation and restoration of the olfactory topographic map

Article Abstract:

Research demonstrates that ensuing a genetic ablation of the neuronal cells expressing specific odorant receptors, the sensory map is restored unaltered suggesting that the information for establishing the sensory map extends over the life of the organism.

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Axonal ephrin-as and odorant receptors: coordinate determination of the olfactory sensory map

Article Abstract:

Research shows that neurons expressing different odorant receptors express ephrin-A protein at different concentrations on their axons. Results demonstrate that ephrin-A molecules, together with odorant receptors, are involved in the formation of a sensory map in the olfactory bulb.

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Odorant receptors govern the formation of a precise topographic map

Article Abstract:

A study was conducted to demonstrate that deletions or nonsense mutations in the P2 odorant receptor gene cause the axons of olfactory neurons to wander rather than converge on a specific glomerulus. Receptor substitution experiments that replace the P2 gene with the coding region of the P3 gene result in the projection of P3 to P2 axons to a glomerulus touching the wild-type P3 glomerulus. These data indicate that the odorant receptor plays an instructive role in the establishment of the topographic map of odor quality.

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