Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

Article Abstract:

Autophagy, a catabolic process involving self-digestion of cellular organelles, was studied. It was shown that allelic loss of beclin1 and defective autophagy sensitized mammary epithelial cells to metabolic stress and it was proposed that autophagy limits metabolic stress to protect the genome and that defective autophagy increases DNA damage and genomic instability that facilitates breast cancer progression.

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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

Article Abstract:

Antiapoptitic BCL-2 family proteins that promoted tumor formation of transformed baby mouse kidney (BMK) epithelial cells by antagonizing BAX- and BAK- dependent apoptosis is demonstrated. Examination of the transformed BMK cells in vivo revealed aberrant metaphases and ploidy changes in tumors as early as 9 d after implantation, which progressed in magnitude during the tumorigenic process.

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Exploiting different ways to die

Article Abstract:

Developmental cell death is recognized to play a major role in morphogenesis and tissue sculpting, whereas cell death in mature organisms is essential for tissue homeostasis, wound healing, and elimination of infectious pathogens. Three major types of cell death were distinguished that contribute to proper development and well being that are apoptosis, autophagy, and necrosis.

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