Autophagy in neuronal cell loss: A road to death

Article Abstract:

Evidence has shown that late onset of neuronal cell loss generally occurs via autophagy, which is a process in which eukaryotic cells self-digest parts of their contents during development or to survive starvation. The analysis has suggested that overactivation of autophagy in the cells of the nervous system is the eventual cause of physiological death.

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Neurogenesis in adult CNS: from denial to opportunities and challenges for therapy

Article Abstract:

The methodological, technical and conceptual problems resulting in the historical denial of neurogenesis in adult CNS are discussed. The conflicts to be resolved before neural stem cells (NSC) or endogenous neurogenesis is accepted for therapies are described.

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Chronic activation of ERK and neurodegenerative diseases

Article Abstract:

The chronic activation of extracellular-signal regulated kinases (ERK) plays an important role in the pathogenesis of neurodegeneration. Findings that support the notion that the kinetics and localization of ERK are intrinsically linked are presented.

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