Attacin - an insect immune protein - binds LPS and triggers the specific inhibition of bacterial outer-membrane protein synthesis

Article Abstract:

Experiments were performed showing that lipopolysaccharide (LPS) on the cell surface acts as the receptor for attacin, a 20 kDa antibacterial protein from the immune haemolymph of Hyalophora cecropia. Results also showed that attacin does not produce any inhibitory effect on cell growth when reacted with purified LPS. Moreover, it was also observed that attacin need not enter the inner membrane of the cytoplasm to interfere with the synthesis of the outer membrane protein of the cell.

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Bacterial senescence: stasis results in increased and differential oxidation of cytoplasmic proteins leading to developmental induction of the heat shock regulon

Article Abstract:

Bacteria, along with all other life forms, may become more fragile as it ages through oxidative sensitivity of TCA cycle enzymes. Levels of oxidized proteins has been correlated to the age of Escherichia-coli culture, and this increase is higher in cells that lack the global regulators OxyR and sigma(super)s. Protein oxidation signals induction of the heat shock regulon.

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Novel Helicobacter pylori alpha1,2-fucosyltransferase, a key enzyme in the synthesis of Lewis antigens

Article Abstract:

Research was conducted to express, characterize and compare alpha1,2-fucosyltransferase of Helicobacter pylori with the mammalian type. Results show the enzyme can be overproduced in Escherichia coli, is involved in the synthesis of Lewis antigens of lipopolysaccharide and differs from mammalian enzyme in several properties.

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