Asymmetric and node-specific nodal (ital) expression patterns are controlled by two distinct cis-acting regulatory elements

Article Abstract:

Node-specific and asymmetric nodal expression patterns are regulated by two cis-acting regulatory elements distinct from one another. The cis-regulatory elements that control nodal (ital) expression domains in early development have been analyzed. Regulatory sequences that confer node-specific expression are in an upstream region of the locus. Early expression in the epiblast and endoderm and asymmetric expression at later stages on the left side of the axis of the body are controlled by a 600-bp intronic enhancer. Developmentally regulated nodal (ital) expression at certain tissue locations in left-right (L-R) and anterior-posterior (A-P) formation is potentially controlled by shared transcriptional activators.

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Cell fate decisions within the mouse organizer are governed by graded Nodal signals

Article Abstract:

Research has been conducted on cell fate decisions. Results demonstrate that these decisions are governed by graded Noda1/Smad2 signals, and that Smad2-dependent signals regulate the formation of PCP precursor populations and the definitive endoderm.

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RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development

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Research has been conducted on small GTPase RhoB. The authors have investigated the role of RhoB in vascular development and its signaling in angiogenesis.

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