Association analysis of IL1A and IL1B variants in alopecia areata

Article Abstract:

Association analysis of IL1A and IL1B variants is discussed relative to alopecia areata, an inflammatory hair loss disease with a major genetic component. Strong linkage disequilibrium exists between IL1A+ 4845 and IL1B+395. Weak linkage disequilibrium is seen between IL1B-511 and the other two markers. Results suggest possibility of an association with IL1A+4845 in the total dataset but this was not statistically significant. The contribution from mild cases of alopecia areata is a factor, and IL1(alpha) may have a certain role in the pathogenesis of this subgroup.

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Development and characterization of DNA sequence OmyP9 associated with the sex chromosomes in rainbow trout

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The DNA sequence OmyP9 associated with the sex chromosomes in rainbow trout is discussed relative to its development and characterization. Omyp9 is a sequence characterized amplified DNA region and was derived from a RAPD marker associated with the sex chromosomes in rainbow trout.

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A unique cause of linkage disequilibrium in natural populations of Drosophila robusta

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A novel cause of disequilibrium of linkage in natural populations of Drosophila robusta which has been studied in connection with linkage in populations is discussed. Paracentric inversions on the two arms of the metacentric second chromosome are in many cases responsible.

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