Article Abstract:
In eukaryotes initiation sites of chromosomal DNA replication are thought to be determined partly by binding of a heteromeric origin recognition complex (ORC) to DNA. Genes encoding subunits of Drosophila ORC have been cloned. Each gene is unique and can be mapped to a discrete chromosome location. This would indicate that the pattern and developmental regulation of origin usage in Drosophila might not be regulated by a large family of different ORC proteins alone. The 6-subunit ORC can be put back together with recombinant proteins into a complex that restarts DNA replication in ORC-depleted Xenopus or Drosophila egg extracts.
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Article Abstract:
The Drosophila sticks-and-stones (sns) locus has been identified based on its mutant phenotype, absence of body wall muscles and presence of unfused myoblasts. The genetic location of the mutation that brings on the apparent defect in myoblast fusion has been found by recombination and deficiency mapping. Drosophila SNS has been found to be a member of the immunoglobulin superfamily required for myoblast fusion.
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Article Abstract:
The Drosophila gene members only (mbo) has been found to encode a nucleoporin necessary for Rel protein import and immune-response activation. The nucleoporin is homologous to the mammalian Nup88. Study results show certain nuclear import events require different nucleoporins in vivo and suggest mbo has a regulatory function in signal transduction.
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