Arginine methylation of STAT1 modulates IFN(alpha)/beta-induced transcription

Article Abstract:

Research has been conducted on the interferon transcriptional induction requiring tyrosine and serine phosphorylation of signal transducers and activators of transcription (STAT) factors. The arginine methylation of STAT1 by protein arginine methyl-transferase as a requirement for the IFN(alpha)/beta-induced transcription has been carried out and the results are reported.

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Aging reduces proliferative capacities of liver by switching pathways of C/EBP(alpha) growth arrest

Article Abstract:

Research has been conducted on liver specific protein C/EBP(alpha) which arrests hepatocyte proliferation via cyclin dependent kinase inhibition. The authors demonstrate that aging leads liver-specific pathways of C/EBP(alpha) growth arrest to E2F transcription repression.

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State of the Arg: protein methylation at arginine comes of age

Article Abstract:

The authors review publications on posttranslation protein modification. The topics of interest include the methylation and methyltransferase enzyme function, the effect of the argenine methylation on the protein-protein interactions and the roles of methylation.

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