Arginine methylation facilitates the nuclear export of hnRNP proteins

Article Abstract:

An in vivo nuclear export assay has been used to study arginine methylation for nuclear export of the heterogeneous nuclear ribonucleoproteins (hnRNPs). Various hnRNPs help in eukaryotic mRNA processing/export. Both Np13p and Hrp1p fail to leave the nucleus in cells without Hmt1p. Overexpression of Hmt1p helps in Np13p export. A genetic relationship exists between Mnt1p and cap-binding protein 80 (CBP80). Arginine methylation helps in nuclear export of hnRNP proteins. That is at least one of its biological roles. In Saccharomyces cerevisiae, the enzyme mainly responsible for arginine methylation is Hmt1p.

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A systems view of mRNP biology

Article Abstract:

In order to understand gene expression's pathways, properties and behaviors as a system, their processes are increasingly studied from global perspectives. The beginnings of mRNA-protein (mRNP) systems biology, as they have emerged from large-scale investigation of mRNP components, interactions and dynamics are reviewed.

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Definition of global and transcript-specific mRNA export pathways in metazoans

Article Abstract:

The various factors involved in the global and transcript-specific mRNA export pathways in metazoans are analyzed. These factors associate with polysomes and facilitate the mRNA transport.

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