Apoptotic pathways: the roads to ruin

Article Abstract:

The response to cellular stress or to disruption of cell cycle controls during cell development is for cells to engage the pathways that activate endogenous caspases which bring about the death of the cells by apoptosis so that effective and silent clearing can take place. The nature of these pathways is now becoming more apparent, but further research must still be undertaken into how developmental signals or stress responses engage these pathways.

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Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICe

Article Abstract:

Research was conducted to study the inactivation of casp-11, a member of the Ice/Ced-3 family of cell death genes. Several primers were utilized for sequencing the genomic clone to locate the position of the intron-exon boundary while blastocytes were microinjected with 10-12 J1 cells from a single targeted clone. Results indicated that casp-11 resisted lipopolysaccharide-induced lethality and showed that it can be induced up to 40-fold.

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Protease activation during apoptosis: death by a thousand cuts?

Article Abstract:

Proteases of the interleukin-1-beta-converting enzyme family are good regulators or components of the cell death machinery. All the components of the cell death machinery are required for cell growth as well as cell death. Enucleated studies indicate that the central components of the cell death machinery are localized to the cystol.

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