Antisense transcription controls cell fate in Saccharomyces cerevisiae

Article Abstract:

The meiotic entry in Saccharomyces cerevisiae is controlled by antisense-mediated regulation of Initiator of Meiosis 4 (IME4), a gene required for initiating meiosis. The strength of the promoter driving either sense or antisense transcription from the IME4 locus is found to be cell-type specific and IME4 sense transcription has determined a cell-type capable of meiosis, whereas IME4 antisense transcription has determined a cell-type incapable of meiosis.

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Degradation-mediated protein quality control in the nucleus

Article Abstract:

The discovery of protein quality control degradation systems in Saccharomyces cerevisiae is reported that is defined by San1p. It is proposed that San1p-mediated degradation acts as the last line of protreolytic defense against the deleterious accumulation of aberrant proteins in the nucleus and that analogous systems exist in other eukaryotes.

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Mechanism of cross-species prion transmission: An infectious conformation compatible with two highly divergent yeast prion proteins

Article Abstract:

The relationship between prion strains and species barriers is explored by creating distinct synthetic prion forms of the yeast prion protein Sup35. A strain conformation of Sup35 that allows transmission from the S. cerevisiae (Sc) Sup35 to the highly divergent C. albicans (Ca) Sup35 both in vivo and in vitro is identified.

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