Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

Article Abstract:

Research shows that antigen receptor activation plays an important role in transcription factor processes. Activation results in BCL-6 phosphorylation through mitogen-activated protein kinase, which degrades BCL-6 through the ubiquitin/proteasome pathway. This finding indicates that antibody response and B-cell differentiation can be controlled via the activation process, possibly preventing B-cell lymphoma pathogenesis.

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

Article Abstract:

The inositol 5-phosphatase SHIP plays a key role in down-regulating serine/threonine protein kinase B, or PKB. Studies of SHIP-deficient mice show market levels of myeloid cell hyperplasia in the spleen and bone marrow. Organs exhibited myeloid infiltration. SHIP-deficient myeloid cells are not significantly affected by growth factor withdrawal and sustain high levels of PKB activation.

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Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair

Article Abstract:

Research was conducted to identify and characterize the autonomously replicating sequence binding factor 1 (ABF1) from yeast. Data indicate that ABF1 is a DNA-binding protein and plays a direct role in nucleotide excision repair in yeast.

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