Article Abstract:
Ectopic expression of the Sonic hedgehog (shh/vhh-1) gene on the anterior margin of the bud below the apical ectoderm ridge is caused by the administration of retinoic acid (RA) to the zebrafish embryos during the beginning of the pectoral fin bud formation. Abnormal morphology of the fin buds and ectopic expression of shh/vhh-1 in the floor plate cells of the caudal end of the neural keel is also seen. The results of this study show that the beginning stages of the development of the limbs in fish and tetrapods are similar.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A 14 kDa S-lectin called galectin-7 has been isolated in cultures of human skin cells. The expression of this lectin in keratinocyte cultures was inhibited by retinoic acid, which is involved in the growth and differentiation of skin. It appears to be expressed in all layers of skin and has a different sequence than other S-lectins.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
Retinoic acid changes the normal distribution of cellular retinoic acid binding protein I (CRABP-I) in the developing mouse brain. Initially, CRABP-I is expressed in the hindbrain and the neural crest. Retinoic acid treatment upregulates CRABP-I expression and anteriorizes it. Retinoic acid may have a similar effect on Hox genes.
User Contributions:
Comment about this article or add new information about this topic: