Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed

Article Abstract:

Regulators of G protein signaling (RGS proteins) have been studied in Caenorhabditis elegans. Three of the 13 RGS genes analyzed were found to influence egg-laying behavior and two seem to redundantly change signaling to bring on appropriate behavioral responses to feeding.

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daf-28 encodes a C. elegans insulin superfamily member that is regulated by theenvironmental cues and acts in the DAF-2 signaling pathway

Article Abstract:

It has been found that daf-28, which acts in the DAF-2 signaling pathway , encodes a Caenorhabditis elegans insulin superfamily member regulated by environmental cues. Of the 38 C. elegans insulin genes, daf-28 is the only insulin mutant thusfar found to affect dauer arrest.

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Antagonism between G(sub.o)alpha and G (sub.q)alpha in Caenorhabditis elegans: The RGS protein EAT-16 is necessary for G(sub.o)alpha signaling and regulates G (sub.q)alpha activity

Article Abstract:

Antagonism between G(sub.o)alpha and G(sub.q)alpha in Caenorhabditis elegans is discussed in light of the finding that EAT-16, an RGS protein, regulates G(sub.q)alpha activity and is necessary for G(sub.o)alpha signaling. Research based on a molecular genetic approach in C. elegans was undertaken to look into the cellular role of the heterotrimeric G. protein G(sub.o) and it is proposed that a major role of G(sub.o) in the cell is antagonizing signaling by G(sub.q).

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