Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)

Article Abstract:

The report demonstrates that Ang-1, via Akt activation, is a potent inhibitor of the forkhead transcription factor FKHR (FOXO1), identifying for the first time a nuclear signaling pathway through which Ang-1 modulates gene expression. The data suggests a novel, tissue-specific role for the Akt/FKHR pathway in the vasculature and suggest a mechanistic basis for the actions of Ang-1 as a regulator of endothelial cell survival and blood vessel stability.

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Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1

Article Abstract:

The expression of the Wilms' tumor gene-1, 'Wt1', in coronary vessels, which could contribute to the defective cardiac vascularization in 'Wt1' mice is studied. It is found that transcriptional activation of the TrkB neurotrophin receptor gene by the Wilms' tumor suppressor 'Wt1' is a crucial mechanism for normal vascularization of the developing heart.

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Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: Implications for alveolar rhabdomysarcoma cell of origin

Article Abstract:

A Cre-mediated conditional knock-in of Pax3:Fkhr was generated into the mouse Pax3 locus to investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas. Findings suggest that mature differentiating skeletal muscle and not satellite cells gives rise to alveolar rhabdomyosarcomas.

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