Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

Article Abstract:

The expressions of 49 mouse nuclear receptor (NR) mRNAs in 39 tissues were surveyed to establish the anatomical expression profiles. The data reveal a hierarchical transcriptional circuitry that extends beyond individual tissues to form a meganetwork governing physiology on an organismal scale.

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Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding

Article Abstract:

Research has been conducted on the transcription factor interactions. The x-ray crystal structure of the lambda repressor C-terminal domain determined via multiwavelength anomalous diffraction is described.

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The RNA binding protein Pub 1 modulates the stability of transcripts containing upstream open reading frames

Article Abstract:

Research has been conducted on the nonsense-mediated mRNA decay (NMD) pathway. Prevention of the rapid NMD by a stabilizer element via interaction with the RNA binding protein Pub 1 has been investigated.

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