Analysis of high-resolution HapMap of DTNBP1 (dysbindin) suggests no consistency between reported common variant associations and schizophrenia

Article Abstract:

The HapMap sample (CEU), the high density reference map is used to compare the putative disease associated haplotype and it is demonstrated that the European-derived populations studied have haplotype patterns and frequencies that are consistent with the HapMap CEU sample. The utility of the HapMap in successfully relating association studies that have used diverse market sets, and. furthermore emphasizes the utility of testing a common set of SNPs is highlighted.

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A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to Schizophrenia

Article Abstract:

Random markers on chromosome 11q22-24 were initially selected for fine mapping and confirmation was performed by the study of an Aberdeen sample. The strongest allelic and haplotypic associations were found with markers within FXYD6 gene.

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Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum

Article Abstract:

The article describes about AKT3 that represents an excellent candidate for developmental human MIC and ACC and suggests that haploinsufficiency causes both postnatal MIC and ACC.

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